Adverse drug reactions to antiretroviral therapy during the early art period at a tertiary hospital in Ghana
Identifieur interne : 000527 ( Main/Exploration ); précédent : 000526; suivant : 000528Adverse drug reactions to antiretroviral therapy during the early art period at a tertiary hospital in Ghana
Auteurs : Margaret Lartey [Ghana] ; Abena Asante-Quashie [Ghana] ; Ama Essel [Ghana] ; Ernest Kenu [Ghana] ; Vincent Ganu [Ghana] ; Alfred Neequaye [Ghana]Source :
- The Pan African Medical Journal [ 1937-8688 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Anémie (), Anémie (épidémiologie), Centres de soins tertiaires, Facteurs de risque, Facteurs sexuels, Facteurs temps, Femelle, Ghana (épidémiologie), Humains, Infections à VIH (traitement médicamenteux), Modèles logistiques, Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active (), Thérapie antirétrovirale hautement active (effets indésirables), Études rétrospectives, Études transversales.
- MESH :
- effets indésirables : Agents antiVIH, Thérapie antirétrovirale hautement active.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- épidémiologie : Anémie, Ghana.
- Adulte, Adulte d'âge moyen, Anémie, Centres de soins tertiaires, Facteurs de risque, Facteurs sexuels, Facteurs temps, Femelle, Humains, Modèles logistiques, Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active, Études rétrospectives, Études transversales.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Anemia (chemically induced), Anemia (epidemiology), Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiretroviral Therapy, Highly Active (adverse effects), Antiretroviral Therapy, Highly Active (methods), CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Ghana (epidemiology), HIV Infections (drug therapy), Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Factors, Sex Factors, Tertiary Care Centers, Time Factors.
- MESH :
- chemical , adverse effects : Anti-HIV Agents.
- geographic , epidemiology : Ghana.
- adverse effects : Antiretroviral Therapy, Highly Active.
- chemically induced : Anemia.
- drug therapy : HIV Infections.
- epidemiology : Anemia.
- methods : Antiretroviral Therapy, Highly Active.
- chemical , therapeutic use : Anti-HIV Agents.
- Adult, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Factors, Sex Factors, Tertiary Care Centers, Time Factors.
Abstract
Antiretroviral therapy (ART) has reduced HIV morbidity and mortality worldwide but has many adverse effects. These adverse drug reactions (ADRs) lead to discontinuations, disease progression or treatment failure. We explored the types and risk factors for ADRs in a cohort starting ART in a teaching hospital in Accra, Ghana where the main regimens used were a combination of nucleotide and non nucleotide reverse transcriptase inhibitors.
A Cross-sectional retrospective study was conducted reviewing data of 2042 patients initiated on HAART from 2003 to 2007. Univariate analysis was done for the dependent and independent variables. Stepwise logistic regression procedures were used to model the effect of gender on the development of ADRs controlling for other variables like age, marital status, weight at baseline and CD4 at baseline.
The period prevalence of ADRs was 9.4%. The two most common adverse reactions were anaemia and diarrhoea. Female sex was a statistically significant independent predictor of an adverse drug reaction (AOR: 1.66, p = 0.01, CI: 1.16-2.36). CD4 counts 250 cells/mm3 or more was significantly associated with the occurrence of an ADR. The occurrence of anaemia in females was statistically significant compared to males.
Adverse drug reactions were less common than expected, anaemia was the commonest ADR. Female sex and high CD4 counts >250mm3 were predictors of ADRs whereas females were significantly more likely to develop anaemia than males. Recommendations were made for interventions to prevent and also mitigate the high levels of anaemia especially among women in the ART scale up.
Url:
DOI: 10.11604/pamj.2014.18.25.3886
PubMed: 25368714
PubMed Central: 4214560
Affiliations:
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Le document en format XML
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Asante-Quashie</name><affiliation wicri:level="3"><nlm:aff id="AF0003">International Organization of Migration, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>International Organization of Migration, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Essel, Ama" sort="Essel, Ama" uniqKey="Essel A" first="Ama" last="Essel">Ama Essel</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Kenu, Ernest" sort="Kenu, Ernest" uniqKey="Kenu E" first="Ernest" last="Kenu">Ernest Kenu</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Ganu, Vincent" sort="Ganu, Vincent" uniqKey="Ganu V" first="Vincent" last="Ganu">Vincent Ganu</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Neequaye, Alfred" sort="Neequaye, Alfred" uniqKey="Neequaye A" first="Alfred" last="Neequaye">Alfred Neequaye</name><affiliation wicri:level="3"><nlm:aff id="AF0001">Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Medicine and Therapeutics, University of Ghana Medical School, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="AF0002">Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author></analytic><series><title level="j">The Pan African Medical Journal</title><idno type="eISSN">1937-8688</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anemia (chemically induced)</term><term>Anemia (epidemiology)</term><term>Anti-HIV Agents (adverse effects)</term><term>Anti-HIV Agents (therapeutic use)</term><term>Antiretroviral Therapy, Highly Active (adverse effects)</term><term>Antiretroviral Therapy, Highly Active (methods)</term><term>CD4 Lymphocyte Count</term><term>Cross-Sectional Studies</term><term>Female</term><term>Ghana (epidemiology)</term><term>HIV Infections (drug therapy)</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Sex Factors</term><term>Tertiary Care Centers</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (effets indésirables)</term><term>Agents antiVIH (usage thérapeutique)</term><term>Anémie ()</term><term>Anémie (épidémiologie)</term><term>Centres de soins tertiaires</term><term>Facteurs de risque</term><term>Facteurs sexuels</term><term>Facteurs temps</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections à VIH (traitement médicamenteux)</term><term>Modèles logistiques</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Thérapie antirétrovirale hautement active ()</term><term>Thérapie antirétrovirale hautement active (effets indésirables)</term><term>Études rétrospectives</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Anemia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents antiVIH</term><term>Thérapie antirétrovirale hautement active</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anemia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Anémie</term><term>Ghana</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>CD4 Lymphocyte Count</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Sex Factors</term><term>Tertiary Care Centers</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anémie</term><term>Centres de soins tertiaires</term><term>Facteurs de risque</term><term>Facteurs sexuels</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Thérapie antirétrovirale hautement active</term><term>Études rétrospectives</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction</title><p>Antiretroviral therapy (ART) has reduced HIV morbidity and mortality worldwide but has many adverse effects. These adverse drug reactions (ADRs) lead to discontinuations, disease progression or treatment failure. We explored the types and risk factors for ADRs in a cohort starting ART in a teaching hospital in Accra, Ghana where the main regimens used were a combination of nucleotide and non nucleotide reverse transcriptase inhibitors.</p></sec><sec id="st2"><title>Methods</title><p>A Cross-sectional retrospective study was conducted reviewing data of 2042 patients initiated on HAART from 2003 to 2007. Univariate analysis was done for the dependent and independent variables. Stepwise logistic regression procedures were used to model the effect of gender on the development of ADRs controlling for other variables like age, marital status, weight at baseline and CD4 at baseline.</p></sec><sec id="st3"><title>Results</title><p>The period prevalence of ADRs was 9.4%. The two most common adverse reactions were anaemia and diarrhoea. Female sex was a statistically significant independent predictor of an adverse drug reaction (AOR: 1.66, p = 0.01, CI: 1.16-2.36). CD4 counts 250 cells/mm3 or more was significantly associated with the occurrence of an ADR. The occurrence of anaemia in females was statistically significant compared to males.</p></sec><sec id="st4"><title>Conclusion</title><p>Adverse drug reactions were less common than expected, anaemia was the commonest ADR. Female sex and high CD4 counts >250mm3 were predictors of ADRs whereas females were significantly more likely to develop anaemia than males. Recommendations were made for interventions to prevent and also mitigate the high levels of anaemia especially among women in the ART scale up.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bonnet, F" uniqKey="Bonnet F">F Bonnet</name></author><author><name sortKey="Morlat, P" uniqKey="Morlat P">P Morlat</name></author><author><name sortKey="Chene, G" uniqKey="Chene G">G Chêne</name></author><author><name sortKey="Mercie, P" uniqKey="Mercie P">P Mercié</name></author><author><name sortKey="Neau, D" uniqKey="Neau D">D Neau</name></author><author><name sortKey="Chossat, I" uniqKey="Chossat I">I Chossat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palella, Fj" uniqKey="Palella F">FJ Palella</name></author><author><name sortKey="Baker, Rk" uniqKey="Baker R">RK Baker</name></author><author><name sortKey="Moorman, Ac" uniqKey="Moorman A">AC Moorman</name></author><author><name 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sortKey="Rezza, G" uniqKey="Rezza G">G Rezza</name></author><author><name sortKey="Pezzotti, P" uniqKey="Pezzotti P">P Pezzotti</name></author><author><name sortKey="Antinori, A" uniqKey="Antinori A">A Antinori</name></author><author><name sortKey="Phillips, An" uniqKey="Phillips A">AN Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cesar, C" uniqKey="Cesar C">C Cesar</name></author><author><name sortKey="Shepherd, Be" uniqKey="Shepherd B">BE Shepherd</name></author><author><name sortKey="Krolewiecki, Aj" uniqKey="Krolewiecki A">AJ Krolewiecki</name></author><author><name sortKey="Fink, Vi" uniqKey="Fink V">VI Fink</name></author><author><name sortKey="Schechter, M" uniqKey="Schechter M">M Schechter</name></author><author><name sortKey="Tuboi, Sh" uniqKey="Tuboi S">SH Tuboi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mocroft, A" uniqKey="Mocroft A">A Mocroft</name></author><author><name sortKey="Youle, M" uniqKey="Youle M">M Youle</name></author><author><name sortKey="Moore, A" uniqKey="Moore A">A Moore</name></author><author><name sortKey="Sabin, Ca" uniqKey="Sabin C">CA Sabin</name></author><author><name sortKey="Madge, S" uniqKey="Madge S">S Madge</name></author><author><name sortKey="Lepri, Ac" uniqKey="Lepri A">AC Lepri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name></author><author><name sortKey="Vallabhaneni, S" uniqKey="Vallabhaneni S">S Vallabhaneni</name></author><author><name sortKey="Cecelia, Aj" uniqKey="Cecelia A">AJ Cecelia</name></author><author><name sortKey="Yepthomi, T" uniqKey="Yepthomi T">T Yepthomi</name></author><author><name sortKey="Balakrishnan, P" uniqKey="Balakrishnan P">P Balakrishnan</name></author><author><name sortKey="Saghayam, S" uniqKey="Saghayam S">S Saghayam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tayal, V" 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uniqKey="Fisher A">AE Fisher</name></author><author><name sortKey="Everhard, F" uniqKey="Everhard F">F Everhard</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Teodor, A" uniqKey="Teodor A">A Teodor</name></author><author><name sortKey="Teodor, D" uniqKey="Teodor D">D Teodor</name></author><author><name sortKey="Luca, V" uniqKey="Luca V">V Luca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbaraman, R" uniqKey="Subbaraman R">R Subbaraman</name></author><author><name sortKey="Chaguturu, Sk" uniqKey="Chaguturu S">SK Chaguturu</name></author><author><name sortKey="Mayer, Kh" uniqKey="Mayer K">KH Mayer</name></author><author><name sortKey="Flanigan, Tp" uniqKey="Flanigan T">TP Flanigan</name></author><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name></author><author><name sortKey="Venkatesh, Kk" uniqKey="Venkatesh K">KK Venkatesh</name></author><author><name sortKey="Cecelia, Aj" uniqKey="Cecelia A">AJ Cecelia</name></author><author><name sortKey="Devaleenal, B" uniqKey="Devaleenal B">B Devaleenal</name></author><author><name sortKey="Lai, Ar" uniqKey="Lai A">AR Lai</name></author><author><name sortKey="Saghayam, S" uniqKey="Saghayam S">S Saghayam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wabe, N" uniqKey="Wabe N">N Wabe</name></author><author><name sortKey="Woldemedhin, B" uniqKey="Woldemedhin B">B Woldemedhin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geretti, Am" uniqKey="Geretti A">AM Geretti</name></author><author><name sortKey="Patel, M" uniqKey="Patel M">M Patel</name></author><author><name sortKey="Sarfo, Fs" uniqKey="Sarfo F">FS Sarfo</name></author><author><name sortKey="Chadwick, D" uniqKey="Chadwick D">D Chadwick</name></author><author><name sortKey="Verheyen, J" uniqKey="Verheyen J">J Verheyen</name></author><author><name sortKey="Fraune, M" uniqKey="Fraune M">M Fraune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name></author><author><name sortKey="Venkatesh, Kk" uniqKey="Venkatesh K">KK Venkatesh</name></author><author><name sortKey="Cecelia, Aj" uniqKey="Cecelia A">AJ Cecelia</name></author><author><name sortKey="Devaleenol, B" uniqKey="Devaleenol B">B Devaleenol</name></author><author><name sortKey="Saghayam, S" uniqKey="Saghayam S">S Saghayam</name></author><author><name sortKey="Yepthomi, T" uniqKey="Yepthomi T">T Yepthomi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Currier, Js" uniqKey="Currier J">JS Currier</name></author><author><name sortKey="Spino, C" uniqKey="Spino C">C Spino</name></author><author><name sortKey="Grimes, J" uniqKey="Grimes J">J Grimes</name></author><author><name sortKey="Wofsy, Cb" uniqKey="Wofsy C">CB Wofsy</name></author><author><name sortKey="Katzenstein, Da" uniqKey="Katzenstein D">DA Katzenstein</name></author><author><name sortKey="Hughes, Md" uniqKey="Hughes M">MD Hughes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name></region><name sortKey="Asante Quashie, Abena" sort="Asante Quashie, Abena" uniqKey="Asante Quashie A" first="Abena" last="Asante-Quashie">Abena Asante-Quashie</name><name sortKey="Essel, Ama" sort="Essel, Ama" uniqKey="Essel A" first="Ama" last="Essel">Ama Essel</name><name sortKey="Ganu, Vincent" sort="Ganu, Vincent" uniqKey="Ganu V" first="Vincent" last="Ganu">Vincent Ganu</name><name sortKey="Kenu, Ernest" sort="Kenu, Ernest" uniqKey="Kenu E" first="Ernest" last="Kenu">Ernest Kenu</name><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name><name sortKey="Neequaye, Alfred" sort="Neequaye, Alfred" uniqKey="Neequaye A" first="Alfred" last="Neequaye">Alfred Neequaye</name><name sortKey="Neequaye, Alfred" sort="Neequaye, Alfred" uniqKey="Neequaye A" first="Alfred" last="Neequaye">Alfred Neequaye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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